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  4. Gibco™ Human BMP-2 Recombinant Protein

Gibco™ Human BMP-2 Recombinant Protein

Product Code. 10053484
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Quantity:
1 mg
10 μg
100 μg
25 μg
Unit Size:
Each
Product Code. Quantity unitSize
10053484 100 μg Each
10329114 1 mg Each
10432565 10 μg Each
10318624 25 μg Each
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Product Code. 10053484

Brand: Gibco™ PHC7141

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Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤ -20°C. Make any further dilutions of the reconstituted protein in low endotoxin medium or a buffered solution containing a carrier protein such as heat inactivated FCS or tissue culture grade BSA. Storage: Store the lyophilized protein at 2-8°C or -2°C for long term storage, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C. Avoid repeated freeze-thaw cycles.

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P12643
For Use With (Application) Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 650
Molecular Weight (g/mol) 25 kDa
Name Human BMP-2
Purification Method Purified
Quantity 100 μg
Storage Requirements 4°C
Regulatory Status RUO
Endotoxin Concentration <0.1 ng/μg
Gene Alias 2610024H22Rik; AI467020; AL117858; AW546137; BB189135; BDA2; BMP; BMP2; BMP-2; BMP2A; BMP-2A; BMPRII; BMPR-II; Bone morphogenetic; Bone morphogenetic protein; Bone morphogenetic protein 2; bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A); bone morphogenetic protein 2A; H-BMP-2; morphogen
Common Name BMP-2
Cell Type Stem Cells
Gene Symbol BMP2
Biological Activity ED50 < 1.0 μg/mL; determined by the dose-dependent induction of alkaline phosphatase in mouse ATDC52 chondrogenic cells.
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Sequence QAKHKQRKRL KSSCKRHPLY VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR
Content And Storage 4°C
Classification Carrier-Free
Activity ED50 < 1.0 μg/mL; determined by the dose-dependent induction of alkaline phosphatase in mouse ATDC52 chondrogenic cells.
Endotoxin Level <0.1 ng/μg
Indicator Cell mouse chondrogenic cell line ATDC5
Reactivity Human
Shipping Condition Wet Ice
Specific Activity 1.0 x 104 - 1.0 x103 units⁄mg
Expression System E. coli
Protein Family Growth Factors & Receptors
Protein Form Recombinant, Ligand
Form Lyophilized
Protein Subtype BMPs (Bone Morphogenetic Proteins) & Related Factors
Research Category Stem Cell Research, Bone Research
Product Line Gibco
Purity or Quality Grade >95% by SDS-PAGE
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