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Gibco™ Human ApoE3 Recombinant Protein, PeproTech®

Product Code. 17852043
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Quantity:
100 μg
2 x 500 μg
500 μg
Unit Size:
100µg
1mg
500µg
Pack of 2
Product Code. Quantity unitSize
17852043 500 μg 500µg
17802613 100 μg 100µg
17882703 2 x 500 μg 1mg
30088565 2 x 500 μg Pack of 2
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Product Code. 17852043

Brand: Gibco™ 35002500UG

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This item is not returnable. View return policy

Description

Recombinant Protein

350-02-1MG will be provided as 2 x 500 μg (350-02-500UG). Recombinant Human ApoE3 is a 34.4 kDa protein containing 300 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P02649
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 348
Molecular Weight (g/mol) 34.4 kDa
Name Human ApoE3
Quantity 500 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias ApoE
Common Name ApoE3
Gene Symbol APOE
Biological Activity Determined by its ability to stimulate the proliferation of human SH-SY5Y cells.
Conjugate Unconjugated
Recombinant Recombinant
Sequence MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 90% by SDS-PAGE gel and HPLC analyses.
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