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HTR1B Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand: Invitrogen PA565031

Product Code. 15957804

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Description

Immunogen sequence: MEEPGAQCAPP PPAGSETWVP QANLSSAPSQ NCSAKDYIYQ DS Highest antigen sequence identity to the following orthologs - mouse 67%, rat 72%.

Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.

Specifications

Antigen	HTR1B
Classification	Polyclonal
Conjugate	Unconjugated
Gene	HTR1B
Gene Alias	5-HT<1B> receptor; 5ht1b; 5-HT1B; 5-HT-1B; 5HT1B Receptor; 5-HT1B receptor; 5-HT1B serotonin receptor; 5-HT1DB; 5-HT-1D-beta; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; HTR1B; HTR1D2; HTR1DB; S12; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin 1D beta receptor; Serotonin receptor 1B
Host Species	Rabbit
Purification Method	Antigen affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	3351
Content And Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form	Liquid

Applications	Immunocytochemistry, Immunohistochemistry
Concentration	0.05 mg/mL
Formulation	PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.	P28222
Gene Symbols	HTR1B
Immunogen	Recombinant Human HTR1B
Quantity	100 μL
Primary or Secondary	Primary
Target Species	Human
Product Type	Antibody
Isotype	IgG

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HTR1B Polyclonal Antibody, Invitrogen™

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