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Invitrogen™ HBG2 Polyclonal Antibody

Description
Recommended positive controls: U87-MG. Predicted reactivity: Rhesus Monkey (97%), Chimpanzee (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Specifications
Specifications
| Antigen | HBG2 |
| Applications | Western Blot |
| Classification | Polyclonal |
| Concentration | 0.71 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 |
| Gene | HBG2 |
| Gene Accession No. | P69892 |
| Gene Alias | abnormal hemoglobin; basic fibroblast growth factor; bFGF; Fgf2; Fgf-2; Fgfb; fibroblast growth factor 2; gamma-2-globin; G-gamma globin Paulinia; Hb F Ggamma; HBG2; HBGF-2; HBG-T1; hemoglobin gamma-2 chain; Hemoglobin gamma-G chain; hemoglobin subunit gamma 2; hemoglobin subunit gamma-2; hemoglobin, gamma G; heparin-binding growth factor 2; methemoglobin; TNCY |
| Gene Symbols | HBG2 |
| Show More |
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