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Harmine, 98+%

Product Code. 11359615
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Quantity:
250 mg
1 g
Unit Size:
1g
250mg
Product Code. Quantity unitSize
11359615 250 mg 250mg
11349615 1 g 1g
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Product Code. 11359615

Brand: Thermo Scientific Alfa Aesar L19068.MD

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Description

CAS: 442-51-3 | C13H12N2O | 212.25 g/mol

Harmine, inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Harmine, inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.

Solubility
Soluble in DMSO (100 mM), DMF (∼1.5 mg/ml), ethanol (∼1.5 mg/ml), and PBS (pH 7.2, ∼0.25 mg/ml). Insoluble in water.

Notes
Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 442-51-3
Molecular Formula C13H12N2O
Molecular Weight (g/mol) 212.25
MDL Number MFCD00004958
InChI Key BXNJHAXVSOCGBA-UHFFFAOYSA-N
Synonym harmine, 7-methoxy-1-methyl-9h-pyrido 3,4-b indole, banisterine, leucoharmine, telepathine, yageine, yajeine, 7-methoxy-1-methyl-9h-beta-carboline, 9h-pyrido 3,4-b indole, 7-methoxy-1-methyl, banisterin
PubChem CID 5280953
ChEBI CHEBI:28121
IUPAC Name 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
SMILES COC1=CC2=C(C=C1)C1=C(N2)C(C)=NC=C1

Specifications

Melting Point 262°C to 266°C
Odor Odorless
Quantity 250 mg
Beilstein 178813
Merck Index 14,4616
Solubility Information Soluble in DMSO (100 mM),DMF (∽1.5mg/ml),ethanol (∽1.5mg/ml),and PBS (pH 7.2,∽0.25mg/ml). Insoluble in water.
Formula Weight 212.25
Percent Purity ≥98%
Chemical Name or Material Harmine

RUO – Research Use Only

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