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HAP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 25133-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16883675

  • 1281.92 NOK / 20µL
Estimated Shipment: 20-12-2022
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Description

Description

Huntington′s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
Specifications

Specifications

HAP1
Polyclonal
Unconjugated
HAP1
HAP 1, HAP1, HAP2, hHLP1, HIP5, HLP, HLP1, Neuroan 1
Rabbit
Antigen Affinity Chromatography
RUO
15114, 9001
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunofluorescence
0.41 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O35668, P54257
HAP1
HAP1 Fusion Protein Ag17705
20 μL
Primary
Human, Mouse
Antibody
IgG
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