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Guggulsterone, MedChemExpress

Product Code. p-200098137
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Product Code. 16480497

Brand: Medchem Express HY107738

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Description

MedChemExpress Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii.

Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

Specifications

Chemical Name or Material Guggulsterone
Physical Form Solid
CAS 95975-55-6
Color White
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C21H28O2
For Use With (Application) Cancer-Kinase/protease
Synonym Z/E-Guggulsterone
Solubility Information DMSO : 20.83 mg/mL (66.67 mM; Need ultrasonic)
SMILES C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Molecular Weight (g/mol) 312.45
Formula Weight 312.45
Percent Purity 99.5%
Grade Research
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Research purposes only

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