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Description
The antibody only recognizes isoform 1 of GNRHR. The predicted unmodified molecular weight of the human GNRHR is ∽38 kDa, the larger band (50-60 kDa) is likely to represent a glycosylated form of GNRHR.
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.
Specifications
Specifications
| Antigen | GNRHR |
| Applications | Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.27 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | GNRHR |
| Gene Accession No. | P30968, Q01776 |
| Gene Alias | GnRH R, GnRH receptor, GNRHR, GNRHR1, GRHR, LHRHR, LRHR |
| Gene Symbols | GNRHR |
| Show More |
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