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GNF-7, MedChemExpress

Product Code. 16477017
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Product Code. 16477017 Supplier Medchem Express Supplier No. HY10943

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Description

MedChemExpress GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies.

GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies.

Specifications

Chemical Name or Material GNF-7
CAS 839706-07-9
Color Off-White
Purity Grade Notes Research
Molecular Formula C28H24F3N7O2
Quantity 5 mg
Solubility Information DMSO : ≥ 33 mg/mL (60.27 mM)
SMILES O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Molecular Weight (g/mol) 547.53
Formula Weight 547.53
Percent Purity 98.93%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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