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GLRB Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 15371-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16894524

  • 1281.92 NOK / 20µL
Estimated Shipment: 13-12-2022
to see stock.

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Description

Description

In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutryic acid, serotonin and acetylcholine comprise an evolutionally conserved superfamily of ligand-gated ion channels. The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins, alpha1 through alpha4 and beta, and an associated peripheral membrane protein, which combine to form a chloride-selective ion channel. In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca2+ in the brainstem and midbrain indicate an important role for Ca2+ in modulation of glycinergic synapses.
Specifications

Specifications

GLRB
Polyclonal
Unconjugated
GLRB
GLRB, Glycine receptor subunit beta, glycine receptor, beta
Rabbit
Antigen Affinity Chromatography
RUO
14658, 25456, 2743
-20°C
Liquid
Western Blot
0.18 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P20781, P48167, P48168
GLRB
GLRB Fusion Protein Ag4429
20 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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