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Invitrogen™ FOXP2 Recombinant Human Monoclonal Antibody (RAB-S249)
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Product Code. 30087561
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Quantity:
100 μg
Unit Size:
100µg
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30087561 100 μg 100µg
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Product Code. 30087561 Supplier Invitrogen™ Supplier No. MA551871

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Description

Human Recombinant Monoclonal Antibody

This antibody recognizes FOXP2 (Forkhead box protein P2). It binds to a folded domain, amino acids 306-411. FOXP2 is a transcriptional repressor that plays a role in the specification and differentiation of lung epithelium.

FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
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Specifications

Antigen FOXP2
Applications ELISA, Flow Cytometry, Immunoprecipitation
Classification Recombinant Monoclonal
Clone RAB-S249
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene FOXP2
Gene Accession No. O15409
Gene Alias 2810043D05Rik; AI449000; CAG repeat protein 44; CAG-16; CAGH44; D0Kist7; DKFZp686H1726; forkhead box P2; forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; OTTHUMP00000196932; RGD1559697; SPCH1; TNRC10; trinucleotide repeat containing 10; trinucleotide repeat-containing gene 10 protein
Gene Symbols FOXP2
Host Species Human
Immunogen This antibody was obtained by recombinant antibody (rAb) phage display recognizing FOXP2 protein under non-denaturing conditions.
Purification Method Metal-chelate Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 93986
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype F(ab) κ
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