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Description
FNIP1 encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. Diseases associated with FNIP1 include Birt-Hogg-Dube Syndrome and Pleural Disease.
Specifications
Specifications
| Antigen | FNIP1 |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Polyclonal |
| Concentration | 0.15 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | FNIP1 |
| Gene Accession No. | Q68FD7, Q8TF40 |
| Gene Alias | FNIP1, KIAA1961 |
| Gene Symbols | FNIP1 |
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