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Fluconazole, 99%, Thermo Scientific™
Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.
Brand: Thermo Scientific Alfa Aesar J62015.03
| Quantity | 1g |
|---|
This item is not returnable.
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Description
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants
Chemical Identifiers
| 86386-73-4 | |
| 306.277 | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 3365 | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| C13H12F2N6O | |
| MFCD00274549 | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| CHEBI:46081 | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
Specifications
| 86386-73-4 | |
| C13H12F2N6O | |
| 1g | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol | |
| 3365 | |
| 306.27 | |
| Fluconazole |
| 1.05 | |
| MFCD00274549 | |
| 14,4122 | |
| Soluble indimethylsulfoxide and ethanol. | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O | |
| 306.277 | |
| CHEBI:46081 | |
| 99% |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Fluconazole
Signal Word
- Danger
Hazard Category
- Acute toxicity Category 4
- Serious eye damage/eye irritation Category 2
- Reproductive toxicity Category 1B
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 2
Hazard Statement
- H302-Harmful if swallowed.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H360D-May damage the unborn child.
- H371-May cause damage to organs.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
Supplemental information
- MIXTURE LIST-Contains : Fluconazole
Product Title
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