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Fc Receptor Binding Inhibitor Polyclonal Antibody, Functional Grade, eBioscience™, Invitrogen™
Description
The human FcgammaR-binding inhibitor can be used to inhibit the non-specific Fc-gamma receptor (FcgammaR)-mediated binding of mouse monoclonal antibodies used for flow cytometric analysis of human tissue. Four different classes of Fcgamma receptors have been identified: FcgammaRI (CD64), FcgammaRII (CD32), and FcgammaRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcgammaR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcgammaR varies depending on the isotype of the MAb. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcgammaRs.
Specifications
Specifications
| Antigen | Fc Receptor Binding Inhibitor |
| Applications | Flow Cytometry, Functional Assay |
| Classification | Polyclonal |
| Concentration | 20 μL/Test |
| Conjugate | Functional Grade |
| Formulation | PBS with no preservative; pH 7.2 |
| Gene Alias | Fc blocking; FcR BI; FcR Inhibitor |
| Purification Method | Affinity chromatography |
| Quantity | 50 mg |
| Regulatory Status | RUO |
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