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Invitrogen™ FADD Monoclonal Antibody (FD19)

Product Code. 11503763
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Quantity:
100 μL
Unit Size:
100µL
Product Code. Quantity unitSize
11503763 100 μL 100µL
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Product Code. 11503763

Brand: Invitrogen™ MA120168

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This item is not returnable. View return policy

Description

Mouse Monoclonal Antibody

Recommended positive controls: A431. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FADD
Applications ELISA, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone FD19
Concentration 2.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene FADD
Gene Accession No. Q13158
Gene Alias Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD
Gene Symbols FADD
Host Species Mouse
Immunogen Purified recombinant human FADD.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 266610, 8772
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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