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Tocris Bioscience™ EPPTB
GREENER_CHOICE

Trace amine 1 (TA1) receptor antagonist/inverse agonist

Brand:  Tocris Bioscience™ 4518/10

Encompass

Product Code. 15716196

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Description

Description

EPPTB is a trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).
Specifications

Specifications

N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide
1110781-88-8
10 mg
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