EGFR Monoclonal Antibody (H11), Invitrogen™

Description

MA5-13070 targets Epidermal Growth Factor Receptor in FACS, ICC/IF, IHC (P), IP, and WB applications and shows reactivity with Human and Mouse samples. This antibody is not recommended for mouse lymph node tissue or human breast carcinoma in IHC applications. The MA5-13070 immunogen is hC2 20 d2 cells.

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.