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DR3 Monoclonal Antibody (JD3), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-6603-95
This item is not returnable.
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Description
Description: The JD3 monoclonal antibody reacts with human DR3, also known as Apo-3, WSL-1, TRAMP, LARD, DDR3, and TR3. DR3, a novel death receptor is expressed at low level by monocytes and granulocytes. Interaction of DR3 with its ligand activates NF-kappa B pathway and induces apoptosis. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. JD3 has been reported for use in flow cytometric analysis. Applications Reported: The JD3 antibody has been reported for use in flow cytometric analysis. Applications Tested: The JD3 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells and human DR3-transfected cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
DR3 Monoclonal antibody specifically detects DR3 in Human samples. It is validated for Flow Cytometry
Specifications
| DR3 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| Q93038 | |
| Mouse | |
| 10 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| Flow Cytometry | |
| JD3 | |
| Unconjugated | |
| TNFRSF25 | |
| APO3; Apo-3; apoptosis inducing receptor; apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; DDR3; death domain receptor 3 soluble form; Death receptor 3; death receptor beta; DR3; LARD; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; RP4-650H14.2; TNF receptor superfamily member 25; TNFRSF12; TNFRSF25; TR3; TRAMP; Tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 12; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein); tumor necrosis factor receptor superfamily, member 25; UNQ455/PRO779; WSL; WSL1; WSL-1; WSL-LR | |
| Affinity chromatography | |
| RUO | |
| 8718 | |
| 4° C | |
| Liquid |
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