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DLK-IN-1, MedChemExpress

Product Code. p-200099268
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16487557 5 mg 5mg
16475606 100 mg 100mg
16431077 50 mg 50mg
16423256 25 mg 25mg
16404818 10 mg 10mg
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Product Code. 16487557 Supplier Medchem Express Supplier No. HY114331

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Description

MedChemExpress DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

Specifications

Chemical Name or Material DLK-IN-1
CAS 1620574-24-4
Color White
Purity Grade Notes Research
Molecular Formula C20H24F3N5O2
Quantity 5 mg
Solubility Information DMSO : 62.5 mg/mL (147.60 mM; Need ultrasonic)
SMILES CC(N1C([C@@H]2[C@]3([H])[C@@]2([H])CN(C4COC4)C3)=CC(C5=CN=C(N)C(OC(F)(F)F)=C5)=N1)C
Molecular Weight (g/mol) 423.43
Formula Weight 423.43
Percent Purity 99.41%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neurodegeneration
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Research purposes only

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