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DIO1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11790-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16889093

  • 3468.15 NOK / 150µL
Estimated Shipment: 16-12-2022
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Description

Description

The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3′,5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3′ UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.
Specifications

Specifications

DIO1
Polyclonal
Unconjugated
DIO1
5DI, DIO1, DIOI, ITDI1, TXDI1, Type 1 DI, Type I 5 deiodinase
Rabbit
Antigen Affinity Chromatography
RUO
13370, 1733, 25430
-20°C
Liquid
Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry, Flow Cytometry
0.45 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P24389, P49895, Q61153
DIO1
DIO1 Fusion Protein Ag2410
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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