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Dicer Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA523088
Additional Details : Weight : 0.01000kg
Description
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
DICER1 is a ribonuclease that has been extensively shown to be related to cancer. Small interfering RNAs are generated through DICER, and seem to play important roles in mitosis in normal cells and oncogenesis in mutated cells. DICER1 mutations are associated with blastoma, breast cancer, adenocarcinoma, and pancreatitis. In vision and hearing, DICER1 has been implicated in serious microRNA induced malformations of critical sensory cells. DICER1 is important in myelination and other nervous system protections. Finally, DICER1 is related to cardiovascular diseases, since microRNAs are aberrantly expressed in some pathological conditions.Specifications
| Dicer | |
| Polyclonal | |
| Unconjugated | |
| Q9UPY3, Q8R418 | |
| DICER1 | |
| A synthetic peptide made to an internal region of the human DICER1 protein (within residues 1100-1300). | |
| 50 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin) | |
| 0.56 mg/mL | |
| DICER1 | |
| DCR1, Dicer, HERNA, MNG1, Dicer1, Dcr-1 homolog, K12H4.8-LIKE, dicer 1, double-stranded RNA-specific endoribonuclease, endoribonuclease Dicer, helicase MOI, helicase with RNAse motif, helicase-moi | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 192119, 23405 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |