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ACROBiosystems Cynomolgus Siglec-10 Protein, His Tag
Brand: ACROBiosystems SI0-C52H5-1mg
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Description
The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.2 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.Specifications
| 60.2 kDa | |
| Cynomolgus Siglec-10, His Tag (SI0-C52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - Ala 549 (Accession # A0A2K5WB x 8-1). | |
| -20°C | |
| Siglec-10 | |
| Cynomolgus Monkey | |
| 25 mM MES, 150 mM NaCl, pH5.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |
| 1 mg | |
| Thr 17 - Ala 549 | |
| SIGLEC10,MGC126774,PRO940,Siglec10,SLG2 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |