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ACROBiosystems Cynomolgus Complement C5 Protein, His Tag
Brand: ACROBiosystems CO5-C52Hx-100ug
Additional Details : Weight : 0.00010kg
Description
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
This protein carries a polyhistidine tag at the C-terminus.The mature form of Complement C5 is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. Each α and β chain has a calculated MW of 73.9 kDa (β chain) and 114.9 kDa (αSpecifications
| XP_005580972.1 | |
| 100 μg | |
| Gln 19 - Cys 1676 | |
| Complement C5,C5,CPAMD4 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 73.9 kDa (β chain) and 114.9 kDa (α chain) | |
| Cynomolgus Complement C5, His Tag (CO5-C52Hx) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Cys 1676 (Accession # XP_005580972.1). | |
| -20°C | |
| Complement C5 | |
| Cynomolgus Monkey | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |