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Cyclopiazonic Acid, MP Biomedicals™

Product Code. 11494142 Shop All MP Biomedicals Products
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Product Code. 11494142 Supplier MP Biomedicals Supplier No. 0215889510

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Description

Displays anti-arrhythmic effects. Cyclopiazonic Acid, MP Biomedicals inhibits the sarcoplasmic reticulum Ca2+-ATPase, which induces the release of intracellular stored Ca2+ without increasing IP3 levels.

Cyclopiazonic acid is a highly specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum, completely inhibiting the enzyme at 6-8nmol/mg protein at the low concentration of 0.5-2μM. Cyclopiazonic acid on Langendorff-perfused murine hearts displays anti-arrhythmic effects. Also, administration on rat soleus muscle showed a decrease in hormone-sensitive lipase activity and triacylglycerol hydrolysis.

TRUSTED_SUSTAINABILITY

Specifications

CAS 18172-33-3
Melting Point 237°C to 238°C (literature)
Molecular Formula C20H20N2O3
Quantity 10 mg
Synonym cyclopiazonic acid, alpha-cyclopiazonic acid, unii-x9tly4580z, ccris 4942, alpha-cyclopiazonate, cyclopyazonic acid, 6ar,10z,11as,11br-10-1-hydroxyethylidene-7,7-dimethyl-6a,7,11a,11b-tetrahydro-6h-pyrrolo 1',2':2,3 isoindolo 4,5,6-cd indole-9,11 2h,10h-dione, 9h-pyrrolo 1',2':2,3 isoindolo 4,5,6-cd indol-9-one, 2,6,6a,7,11a,11b-hexahydro-10-acetyl-7,7-dimethyl-11-hydroxy-, 6a-alpha,11a,11b-alpha, 6ar,11as,11br-10-acetyl-9-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-11h-pyrrolo 1',2':2,3 isoindolo 4,5,6-cd indol-11-one, ambotzls-1020
Solubility Information Soluble in chloroform (10mg/mL) or methanol (10mg/mL, clear, bright yellow solution).
InChI Key SZINUGQCTHLQAZ-AFAVFJNCSA-N
SMILES CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O
Molecular Weight (g/mol) 336.391
PubChem CID 54711281
Formula Weight 336.4
Percent Purity >98%
Physical Form Powder
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