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Invitrogen™ COMP Polyclonal Antibody

Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA596435
Description
Immunogen sequence: GQGQSPLGSD LGPQMLRELQ ETNAALQDVR ELLRQQVREI TFLKNTVMEC DACGMQQSVR TGLPSVRPLL HCAPGFCFPG VACIQTESGA RCGPCPAGFT GNGSHCTDVN ECNAHPCFPR VRCINTSPGF RCEACPPGYS G; Positive Samples: SW620, U-251MG, HepG2, MCF7, Mouse skeletal muscle; Cellular Location: extracellular matrix, extracellular space.
COMP is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
Specifications
| COMP | |
| Polyclonal | |
| Unconjugated | |
| COMP | |
| Cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); Comp; EDM1; EPD1; MED; MGC131819; MGC149768; PSACH; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); putative cartilage oligomeric matrix protein; THBS5; Thrombospondin5; Thrombospondin-5; TSP 5; TSP5 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 12845, 1311, 25304 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Immunohistochemistry (Paraffin), Western Blot | |
| 2.56 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| P35444, P49747, Q9R0G6 | |
| COMP | |
| Recombinant protein (or fragment). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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