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Description
Cloxacillin binds to certain penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. It may interfere with autolysin inhibitors. Cloxacillin has many antibiotic uses:
- To treat infections caused by penicillin G-resistant staphylococci
- In studies of the use of topical antibacterial agents for burn and crush wounds
- As an AmpC β-lactamase inhibitor in combination with β-lactam antibiotics
Specifications
Specifications
| Physical Form | Powder |
| CAS | 7081-44-9 |
| pH | 6.0 to 7.5 (literature) |
| Quantity | 25 g |
| Molecular Formula | C19H19ClN3NaO6S |
| Synonym | 5-Methyl-3-(o-chlorophenyl)-4-isoxazolyl] pencillin, cloxacillin sodium |
| Solubility Information | Freely soluble in water (200mg + 4 mL, clear colorless to faint yellow solution) and methanol; soluble in alcohol, ethylene gycol, ethyl, and pyridene. |
| InChI Key | KCUWTKOTPIUBRI-VICXVTCVSA-M |
| SMILES | CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+] |
| IUPAC Name | sodium;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate |
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Safety and Handling
Product Identifier
- Cloxacillin Sodium Salt
- Danger
- Serious eye damage/eye irritation Category 2
- Respiratory sensitiser Category 1
- Skin corrosion/irritation Category 2
- Skin sensitiser Category 1
- Specific target organ toxicity Category 3
- H315-Causes skin irritation.
- H317-May cause an allergic skin reaction.
- H319-Causes serious eye irritation.
- H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- H335-May cause respiratory irritation.
- P101-If medical advice is needed, have product container or label at hand.
- P102-Keep out of reach of children.
- P103-Read label before use.
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P284-¢In case of inadequate ventilation! wear respiratory protection.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P405-Store locked up.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
- MIXTURE LIST-Contains : Cloxacillin Sodium Salt
Product Title
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