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  6. CISD2 Mouse anti-Human, Mouse, Rat, Zebrafish, Clone: 3D7A3, Proteintech

CISD2 Mouse anti-Human, Mouse, Rat, Zebrafish, Clone: 3D7A3, Proteintech

Product Code. 16857635 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16857635 20 μL 20µL
16847635 150 μL 150µL
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Product Code. 16857635

Brand: Proteintech 660821IG20UL

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This item is not returnable. View return policy

Description

Mouse Monoclonal Antibody

This monoclonal antibody is specific to CISD2 and does not cross-react with CISD1.

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Specifications

Antigen CISD2
Applications Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence
Classification Monoclonal
Clone 3D7A3
Concentration 1.65 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CISD2
Gene Accession No. Q7T326, Q8N5K1, Q9CQB5
Gene Alias CDGSH iron sulfur domain 2, CDGSH2, CISD2, CISD2-Specific, ERIS, Miner1, MitoNEET related 1 protein, NAF 1, WFS2, ZCD2
Gene Symbols cisd2
Host Species Mouse
Purification Method Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 295457, 393354, 493856, 67006
Target Species Human, Mouse, Zebrafish, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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