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Description
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Specifications
Specifications
| Antigen | CHD3 |
| Applications | Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.35 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | CHD3 |
| Gene Accession No. | Q12873 |
| Gene Alias | ATP dependent helicase CHD3, CHD 3, CHD3, hZFH, Mi 2a, Mi2 ALPHA, ZFH, Zinc finger helicase |
| Gene Symbols | CHD3 |
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Product Title
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