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Invitrogen™ CDK9 Monoclonal Antibody (K.513.1)

Rabbit Monoclonal Antibody

Brand: Invitrogen™ MA514912

Product Code. 11544881

4265.00 NOK / 100µL

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Description

It is not recommended to aliquot this antibody.

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.

Specifications

Antigen	CDK9
Classification	Monoclonal
Concentration	163 μg/mL
Formulation	0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene Accession No.	P50750, Q5EAB2, Q641Z4, Q99J95
Gene Symbols	CDK9
Immunogen	Synthetic peptide corresponding to residues near the carboxy terminus of human CDK9.
Quantity	100 μL
Primary or Secondary	Primary
Target Species	Human, Mouse, Rat, Canine, Monkey, Bovine, Hamster
Product Type	Antibody
Isotype	IgG

Applications	Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Clone	K.513.1
Conjugate	Unconjugated
Gene	CDK9
Gene Alias	C-2k; CDC2L4; CDC2-related kinase; Cdk9; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; CTK1; cyclin dependent kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK; Tat-associated kinase complex catalytic subunit
Host Species	Rabbit
Purification Method	Affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	100757719, 100855805, 1025, 107951, 362110, 520580
Content And Storage	-20°C
Form	Liquid

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Invitrogen™ CDK9 Monoclonal Antibody (K.513.1)

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Specifications

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