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  6. CD85d (ILT4) Monoclonal Antibody (42D1), Functional Grade, eBioscience™, Invitrogen™

CD85d (ILT4) Monoclonal Antibody (42D1), Functional Grade, eBioscience™, Invitrogen™

Product Code. 17191272
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50mg
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Product Code. Quantity unitSize
17191272 25 mg 25mg
17111282 5 mg 5mg
17101282 50 mg 50mg
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Product Code. 17191272

Brand: Affymetrix eBioscience 165149025

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Description

Rat Monoclonal Antibody

The MAb 42D1 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally, it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection. Crosslinking of the receptor with the MAb 42D1 inhibits calcium flux as well as enhancing HLA-G tetramer staining and restoring the stimulating activity of tolerogenic DC.

CD85d (ILT4) Monoclonal antibody specifically detects CD85d (ILT4) in Human samples. It is validated for Flow Cytometry, Functional Assay
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD85d (ILT4)
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
Clone 42D1
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene LILRB2
Gene Accession No. Q8N423
Gene Alias CD85 antigen-like family member D; CD85D; CD85d antigen; Ig-like transcript 4; ILT4; ILT-4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin like receptor B2; leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRB2; LIR2; LIR-2; LIR2CD85D; MIR10; MIR-10; MIR10LILRA6; monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10288
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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