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  6. CD369 (Clec7a, Dectin-1) Monoclonal Antibody (15E2), Functional Grade, eBioscience™, Invitrogen™

CD369 (Clec7a, Dectin-1) Monoclonal Antibody (15E2), Functional Grade, eBioscience™, Invitrogen™

Product Code. 17141612
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Product Code. 17141612 Supplier Affymetrix eBioscience Supplier No. 16985638

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Description

Mouse Monoclonal Antibody

This 15E2 MAb reacts with human and Non-human Primate CD369, which is also known as the Dectin-1 or beta-glucan receptor or CLEC7A. CD369 is expressed predominantly on monocytes, macrophages, and dendritic cells. Moreover, this receptor can also be detected on neutrophils and lymphocytes, as well as induced by cytokines such as IL-4 or LPS. In humans, CD369 exists as two isoforms that arise due to alternative splicing. CD369 binds beta-1,3-glucan and plays an important role in activating signal transduction involved in the innate immune response to fungal and mycobacterial infections. Studies have also shown the involvement of CD369 in dendritic cell activation. The 15E2 MAb has been reported to recognize both isoforms of CD369 and activate dendritic cells. It does not crossreact to mouse CD369.

CD369 (Clec7a, Dectin-1) Monoclonal antibody specifically detects CD369 (Clec7a, Dectin-1) in Human, Non-human Primate samples. It is validated for Functional Assay
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD369 (Clec7a, Dectin-1)
Applications Functional Assay
Classification Monoclonal
Clone 15E2
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Clec7a
Gene Accession No. Q9BXN2
Gene Alias beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082
Host Species Mouse
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64581
Target Species Human, Non-human Primate
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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