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CD23 Monoclonal Antibody (B3B4), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
14440.00 NOK - 36070.00 NOK
Specifications
Antigen | CD23 |
---|---|
Clone | B3B4 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry, Immunohistochemistry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17190442
|
Affymetrix eBioscience
14-0232-37 |
2 mg |
14440.00 NOK
2mg |
Estimated Shipment: 02-05-2024 Log in to see stock. |
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17100452
|
Affymetrix eBioscience
14-0232-95 |
10 mg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on resting conventional B cells, and its expression is modulated upon B-cell activation. B-1 cell lineage (CD5+ B cells) does not express CD23. Soluble forms of the antigen have been reported to be biologically active. CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B-cell activation. CD21 is thought to bind to CD23. Applications Reported: The B3B4 antibody has been reported for use in flow cytometric analysis, and immunohistochemical staining. Applications Tested: The B3B4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.Specifications
CD23 | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
14128 | |
Primary | |
4° C | |
Fcer2a |
B3B4 | |
Flow Cytometry, Immunohistochemistry | |
Unconjugated | |
Rat | |
Mouse | |
P20693 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |