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CD23 Monoclonal Antibody (B3B4), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

14440.00 NOK - 36070.00 NOK

Specifications

Antigen CD23
Clone B3B4
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17190442
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Affymetrix eBioscience
14-0232-37
2 mg
14440.00 NOK
2mg
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17100452
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Affymetrix eBioscience
14-0232-95
10 mg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein. CD23 is expressed on resting conventional B cells, and its expression is modulated upon B-cell activation. B-1 cell lineage (CD5+ B cells) does not express CD23. Soluble forms of the antigen have been reported to be biologically active. CD23 is a low affinity receptor for IgE and is thought to play a role in the regulation of IgE response and B-cell activation. CD21 is thought to bind to CD23. Applications Reported: The B3B4 antibody has been reported for use in flow cytometric analysis, and immunohistochemical staining. Applications Tested: The B3B4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
Specifications

Specifications

CD23
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
14128
Primary
4° C
Fcer2a
B3B4
Flow Cytometry, Immunohistochemistry
Unconjugated
Rat
Mouse
P20693
IgG2a κ
Affinity chromatography
Antibody
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