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CD180 (RP105) Monoclonal Antibody (MHR73-11), Functional Grade, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 16-1809-050
This item is not returnable.
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Description
The MHR73-11 MAb reacts with human CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germinal center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and DNA synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.
CD180 (RP105) Monoclonal antibody specifically detects CD180 (RP105) in Human samples. It is validated for Flow Cytometry, Functional Assay
Specifications
| CD180 (RP105) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| Q99467 | |
| Mouse | |
| 50 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| Flow Cytometry, Functional Assay | |
| MHR73-11 | |
| Functional Grade | |
| Cd180 | |
| Cd180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; Radioprotective 105 kDa protein; RP105 | |
| Affinity chromatography | |
| RUO | |
| 4064 | |
| 4° C | |
| Liquid |