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CD123 (IL-3Rα) Mouse, anti-Human, Unconjugated, Clone: 6H6, STEMCELL Technologies
Mouse Monoclonal Antibody
Brand: Stemcell Technologies 60110.1
This item is not returnable.
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Description
- The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit α), an ∼70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily
- CD123 constitutes the ligand-binding α chain of the heterodimeric IL-3 receptor
- CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing β chain of the receptor), high-affinity binding of IL-3 is observed
- CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF)
- IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells
- The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor
Specifications
| CD123 (IL-3Rα) | |
| Monoclonal | |
| Unconjugated | |
| 25 μg | |
| Rhesus Monkey, Sooty Mangabey, Human | |
| Dendritic Cells, Granulocytes and Subsets, Hematopoietic Stem and Progenitor Cells, Myeloid Cells |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| 6H6 | |
| Mouse | |
| Primary | |
| IgG1 κ |