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Description
Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
Specifications
Specifications
| Antigen | CALN1 |
| Applications | Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin) |
| Classification | Polyclonal |
| Concentration | 0.53 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | CALN1 |
| Gene Accession No. | Q06BI3, Q9BXU9, Q9JJG7 |
| Gene Alias | CaBP8, Calcium binding protein 8, CALN1, calneuron 1, Calneuron I |
| Gene Symbols | Caln1 |
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Product Title
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