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BX795, MedChemExpress

Product Code. 16464018
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Product Code. Quantity unitSize
16464018 10 mg 10mg
16442936 25 mg 25mg
16410996 200 mg 200mg
16410377 50 mg 50mg
16406737 5 mg 5mg
16405016 100 mg 100mg
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Product Code. 16464018

Brand: Medchem Express HY10514

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Description

MedChemExpress BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKɛ, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy.

BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKɛ, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy.

Specifications

Chemical Name or Material BX795
Physical Form Solid
CAS 702675-74-9
Color Light Gray
Quantity 10 mg
Purity Grade Notes Research
Molecular Formula C23H26IN7O2S
For Use With (Application) Cancer-Kinase/protease
Solubility Information DMSO : 33.33 mg/mL (56.35 mM; Need ultrasonic)
SMILES O=C(NCCCNC1=C(C=NC(NC2=CC=CC(NC(N3CCCC3)=O)=C2)=N1)I)C4=CC=CS4
Molecular Weight (g/mol) 591.47
Formula Weight 591.47
Percent Purity 98.93%
Grade Research
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Research purposes only

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