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Invitrogen™ beta-2 Microglobulin Monoclonal Antibody (B2M-01)

Product Code. 11564522
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Quantity:
100 μg
Unit Size:
100µg
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11564522 100 μg 100µg
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Product Code. 11564522 Supplier Invitrogen™ Supplier No. MA119141

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Description

Mouse Monoclonal Antibody

This antibody reacts with soluble beta2-microglobulin. Beta2M is a 12 kDa Ig like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells and epithelial cells. It is absent on erythrocytes. It will not cross-react with mouse, rabbit, canine, chicken or bovine. Western Blot: Both reducing and non-reducing conditions. Non-reducing conditions preferred; RIA: Use at an assay dependent concentration. The dissociation constant of the antibody soluble beta2-microglobulin is 1.5 x 10^-8 mol/L as determined by competitive RIA.

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
TRUSTED_SUSTAINABILITY

Specifications

Antigen beta-2 Microglobulin
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Radioimmune Assays (RIA), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone B2M-01
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene B2m
Gene Accession No. P61769
Gene Alias B2m; B2-microglobulin; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; Beta2 microglobulin; beta-2 microglobulin; beta-2 microglobulin preprotein; beta2m; beta2-m; beta-2-microglobin; beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta-2-microglobulin form pI 5.3; B-F; CDABP0092; HDCMA22P; IMD43; Lactollin; Ly-m11; MHC Class I; microglobulin beta-2; Orla-B2m
Gene Symbols B2m
Host Species Mouse
Immunogen Purified human beta-2 Microglobulin.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 567
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a
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