missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Bcl-rambo Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA520000
Additional Details : Weight : 0.01000kg
Description
A suggested positive control is K562 cell lysate. PA5-20000 can be used with blocking peptide PEP-0122.
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.Specifications
Bcl-rambo | |
Polyclonal | |
Unconjugated | |
BCL2L13 | |
BCL2 like 13; BCL2L13; Bcl2-L-13; BCL2-like 13 (apoptosis facilitator); bcl-2-like protein 13; Bcl-rambo; CD003; E430016C20Rik; MIL1; Mil-1; mitochondria located 1 homolog; protein Mil1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
23786, 312682, 94044 | |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunohistochemistry, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
P59017, Q9BXK5 | |
BCL2L13 | |
A 15 amino acid peptide from near the center of human Bcl-rambo. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |