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Invitrogen™ Bcl-10 Monoclonal Antibody (E.177.7)

Description
It is not recommended to aliquot this antibody.
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
Specifications
Specifications
| Antigen | Bcl-10 |
| Applications | Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Clone | E.177.7 |
| Concentration | 32 μg/mL |
| Conjugate | Unconjugated |
| Formulation | 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5 |
| Gene | BCL10 |
| Gene Accession No. | O95999, Q9QYN5, Q9Z0H7 |
| Gene Alias | AI132454; B cell CLL/lymphoma 10; B cell leukemia/lymphoma 10; B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; BCL10; Bcl-10; BCL10 immune signaling adaptor; C81403; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; cE10; c-E10; CED-3/ICH-1 prodomain homologous E10-like regulator; cellular homolog of vCARMEN; Cellular-E10; CIPER; Clap; hCLAP; IMD37; Mamm; mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; RCD; RP11-234D19.2; R-RCD1 |
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