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BABAM1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA564382
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: SLPKLESFNG SKTNALNVSQ KMIEMFVRTK HKIDKSHEFA LVVVNDDTAW LSGLTSDPRE LCSCLYDLET ASCSTFNLEG L Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36.Specifications
BABAM1 | |
Polyclonal | |
Unconjugated | |
BABAM1 | |
5430437P03Rik; BABAM1; BRCA1-A complex subunit MERIT40; BRISC and BRCA1 A complex member 1; BRISC and BRCA1-A complex member 1; C19orf62; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; NBA1; new component of the BRCA1 A complex; new component of the BRCA1-A complex; new component of the BRCAA1 A complex | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
29086 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry | |
Lot-Specific | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q9NWV8 | |
BABAM1 | |
Recombinant protein corresponding to Human BABAM1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only