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AZ304, MedChemExpress

Product Code. 16435656
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Product Code. 16435656 Supplier Medchem Express Supplier No. HY117273

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Description

MedChemExpress AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.

AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.

Specifications

Chemical Name or Material AZ304
CAS 942507-42-8
Color White
Purity Grade Notes Research
Molecular Formula C27H25N5O2
Quantity 100 mg
Solubility Information DMSO : 125 mg/mL (276.84 mM; Need ultrasonic)
SMILES O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
Molecular Weight (g/mol) 451.52
Formula Weight 451.52
Percent Purity 99.96%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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