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ATP citrate lyase Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Shop All Proteintech ProductsDescription
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
Specifications
Specifications
| Antigen | ATP citrate lyase |
| Applications | Immunofluorescence, Western Blot, Flow Cytometry, Immunoprecipitation, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.17 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | ACLY |
| Gene Accession No. | P16638, P53396, Q91V92 |
| Gene Alias | ACL, ACLY, ATP citrate (pro S ) lyase, ATP citrate lyase, ATP citrate synthase, ATPCL, Citrate cleavage enzyme, CLATP |
| Gene Symbols | ACLY |
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