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Invitrogen™ Ataxin 2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA554183
This item is not returnable.
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Description
Immunogen sequence: EGHSINTREN KYIPPGQRNR EVISWGSGRQ NSPRMGQPGS GSMPSRSTSH TSDFNPNSGS DQRVVNGGVP WPSPCPSPSS RPPSRYQSGP NSLPPRAATP TRPPSRPPSR PSRPPSHPSA HGSPAPVSTM PKRMSSE Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.
Specifications
| Ataxin 2 | |
| Polyclonal | |
| Unconjugated | |
| Atxn2 | |
| 9630045M23Rik; ASL13; ataxin 2; ataxin-2; ATX2; Atxn2; AW544490; FLJ46772; SCA2; spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2); spinocerebellar ataxia 2 homolog; spinocerebellar ataxia type 2 protein; Spinocerebellar ataxia type 2 protein homolog; TNRC13; Trinucleotide repeat-containing gene 13 protein | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 6311 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 0.5 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q99700 | |
| Atxn2 | |
| Recombinant protein corresponding to Human Ataxin 2. Recombinant protein control fragment (Product #RP-91710). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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