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ASK1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 28201-1-AP-20UL
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Description
Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.Specifications
| ASK1 | |
| Polyclonal | |
| Unconjugated | |
| MAP3K5 | |
| ASK 1, ASK1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, MEK kinase 5, MEKK 5, MEKK5 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 26408, 4217 | |
| -20°C | |
| Liquid |
| Western Blot, Immunohistochemistry (Paraffin) | |
| 0.47 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| O35099, Q99683 | |
| Map3k5 | |
| ASK1 Fusion Protein Ag28092 | |
| 20 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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