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AR Mouse anti-Human, Clone: 1F7C12, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66747-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16888905

  • 1281.92 NOK / 20µL
Estimated Shipment: 19-12-2022
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Description

Description

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy′s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
Specifications

Specifications

AR
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P10275
AR
AR Fusion Protein Ag17291
20 μL
Primary
Human
Antibody
IgG2a
Immunohistochemistry (Paraffin), Western Blot
1F7C12
Unconjugated
AR
AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Mouse
Protein A
RUO
367
-20°C
Liquid
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SDS
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