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Description
MA1-872 detects AP-2 from human, mouse, and chicken samples. MA1-872 has been successfully used in Western blot, immunoprecipitation, and immunofluorescence applications. By Western blot, this antibody detects a 45-50 kDa band representing AP-2. For Western blotting, block with BSA only (not milk). The MA1-872 immunogen is the N-terminus of human AP2a.
TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.
Specifications
| AP2 alpha | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1mg/mL BSA and 0.05% sodium azide | |
| P05549, P34056 | |
| TFAP2A | |
| N-terminus of human AP2a. | |
| 100 μL | |
| Primary | |
| Chicken, Human, Mouse | |
| Antibody | |
| IgG2b |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 3B5 | |
| Unconjugated | |
| TFAP2A | |
| activating enhancer-binding protein 2 alpha; activating enhancer-binding protein 2-alpha; Activator protein 2; activator protein 2 alpha variant 4; activator protein 2 alpha variant 6; activator protein 2 alpha variant 7; AP2; AP-2; Ap-2 (a); AP-2 transcription factor; AP2alpha; AP-2alpha; AP2-alpha; Ap2tf; BOFS; ERF-1; FLJ51761; OTTHUMP00000214240; OTTHUMP00000214243; Tcfap2a; TFAP2; TFAP2A; transcription factor AP2; transcription factor AP-2 alpha; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); transcription factor AP-2, alpha; transcription factor AP-2-alpha; transcription factor AP-2-alpha-like; transcription factor; AP-2 | |
| Mouse | |
| Protein G | |
| RUO | |
| 21418, 395982, 7020 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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