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Invitrogen™ JMJD2D Polyclonal Antibody
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Product Code. 15524902
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Quantity:
100 μL
Unit Size:
100µL
Product Code. Quantity unitSize
15524902 100 μL 100µL
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Product Code. 15524902

Brand: Invitrogen™ PA541590

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This item is not returnable. View return policy

Description

Rabbit Polyclonal Antibody

Peptide sequence: RAQELTLQTP AKRPLLAGTT CTASGPEPEP LPEDGALMDK PVPLSPGLQH Sequence homology: Human: 100%.

The JMJD2D gene encodes a member of the Jumonji C domain-containing histone demethylases, which are involved in the epigenetic regulation of gene expression by demethylating lysine residues on histone proteins. JMJD2D specifically interacts with β-catenin and is implicated in colorectal cancer, where it activates transcription of target genes and promotes cell proliferation, migration, and tumor formation. Structurally, JMJD2D belongs to the JMJD2 family but exhibits distinct features, lacking certain regions that make it the most structurally divergent within the family. Additionally, JMJD2D stabilizes and cooperates with the hepatitis B virus protein HBx, facilitating cccDNA transcription by demethylating H3K9me3 and counteracting the repressive effects of p53. JMJD2D's role in various cellular processes highlights its importance in both cancer pathogenesis and viral replication, making it a potential target in therapeutic research for colorectal cancer and hepatitis B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JMJD2D
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene KDM4D
Gene Accession No. Q6B0I6
Gene Alias FLJ10251; JHDM3D; JmjC domain-containing histone demethylation protein 3D; JMJD2D; jumonji domain containing 2D; jumonji domain-containing protein 2D; KDM4D; lysine (K)-specific demethylase 4D; lysine demethylase 4D; lysine-specific demethylase 4D
Gene Symbols KDM4D
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal of human JMJD2D (aa 461-510).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55693
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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