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BD Biosciences™ Anti-Human CD4 FITC/CD69 PE/CD3 PerCP (RUO/GMP)

Product Code. 15895858
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50 Tests
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Product Code. Quantity unitSize
15895858 50 Tests Each
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Product Code. 15895858

Brand: BD Biosciences™ 340365

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Description

Monoclonal antibodies for detecting human antigens.

  • Clone SK3 (also known as Leu3a) L78 SK7 (also known as Leu-4) (RUO (GMP))
  • CD4, clone SK3, is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood T lymphocytes.
  • CD69, clone L78, is derived from hybridization of mouse Sp2/0-Ag14 myeloma cells with lymph node cells from BALB/c mice immunized with a CD8+ alloantigen-directed cytotoxic T-lymphocyte (CTL) cell line.
  • CD3, clone SK7, is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human thymocytes.
  • D4 recognizes an antigen that interacts with class II molecules of the major histocompatibility complex (MHC). CD4 is the primary receptor for the human immunodeficiency virus (HIV). The cytoplasmic portion of the antigen is associated with the protein tyrosine kinase p56lck. The CD4 antigen may regulate the function of theCD3 antigen/T-cell antigen receptor (TCR) complex. CD4 also reacts with monocytes/macrophages that have an antigen density lower than that on helper/inducer T lymphocytes. CD69 recognizes a very early human lymphocyte activation antigen.
  • The CD69 antigen is a surface homodimer formed by the association of 28-kilodalton (kd) and 32-kd chains that are held together by disulfide bridges.
  • CD3 recognizes the epsilon chain of the CD3 antigen/T-cell antigen receptor (TCR) complex. This complex is composed of at least six proteins that range in molecular weight from 20 to 30 kd. The antigen recognized by the CD3 antibody is noncovalently associated with either α/β or γ/δ TCR (70 to 90 kd).
  • Contents:
  • Specificity: CD4, Clone: SK3 (Leu3), Format: FITC, Isotype: IgG1K, Entrez Gen ID: 920
  • Specificity: CD69, Clone: L78, Format: PE, Isotype: IgG2aK, Entrez Gen ID: 969
  • Clone: X40, Format PE, Isotype: IgG1K
  • Specificity: CD3, Clone: SK7 (Leu-4), Format: PerCP, Isotype: IgG1K, Entrez Gen ID: 916
  • Research applications include studies of the following:
    • Activated T lymphocytes and T-lymphocyte subsets (helper/suppressor) in peripheral blood.
    • T-lymphocyte activation mechanisms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD4, CD69, CD3
Applications Flow Cytometry
Clone SK3, L78, SK7
Host Species Mouse
Quantity 50 Tests
Regulatory Status RUO
Includes Storage buffer: Phosphate buffered saline with BSA, beta-lactoglobulin, and 0.1% sodium azide.
Target Species Human
Content And Storage Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.
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