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Invitrogen™ AMPK alpha 2 Polyclonal Antibody

Product Code. 17239853 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17239853 100 μL 100µL
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Product Code. 17239853 Supplier Invitrogen™ Supplier No. PA5117354

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Description

Rabbit Polyclonal Antibody

Centrifuge briefly prior to opening.

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AMPK alpha 2
Applications Western Blot
Classification Polyclonal
Concentration 1.06 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene PRKAA2
Gene Accession No. P54646
Gene Alias 2310008I11Rik; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; A830082D05; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP-activated protein kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMPK; AMPK alpha 2; AMPK alpha-2 chain; AMPK subunit alpha-2; AMPK2; AMPKa2; AMPKalpha2; AMPK-alpha-2 chain; EC 2.7.11.1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; PRKAA; Prkaa2; protein kinase AMP-activated catalytic subunit alpha 2; protein kinase, AMP-activated, alpha 2 catalytic subunit
Gene Symbols PRKAA2
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human AMPK alpha 2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5563
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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