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Acalabrutinib, MedChemExpress

Product Code. 16497408
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Product Code. 16497408 Supplier Medchem Express Supplier No. HY17600

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Description

MedChemExpress Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

Specifications

Chemical Name or Material Acalabrutinib
CAS 1420477-60-6
Color Off-White
Purity Grade Notes Research
Molecular Formula C26H23N7O2
Quantity 10 mg
Synonym ACP-196
Solubility Information DMSO : 250 mg/mL (537.05 mM; Need ultrasonic)
SMILES O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
Molecular Weight (g/mol) 465.51
Formula Weight 465.51
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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